?SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME NEW FULLY SUBSTITUTED 1,2,4-TRIAZINES

Authors

  • J M Morsy Chemistry Department, Faculty of Education, Ain-Shams University, Roxy, Cairo, Egypt
  • F Ismail Chemistry Department, Faculty of Education, Ain-Shams University, Roxy, Cairo, Egypt
  • R M Abdel- Rahman Chemistry Department, Faculty of Education, Ain-Shams University, Roxy, Cairo, Egypt
  • H A Amine Chemistry Department, Faculty of Education, Ain-Shams University, Roxy, Cairo, Egypt

Keywords:

Benzoinhydrazide alkylation, 1,2,4-Triazines, Antimicrobial activity.

Abstract

A facile synthesis of fully substituted 1,2,4-triazines (3a-3c) involving the reaction of benzoinhydrazone 1with isothiocyanates
followed by alkylation, hydroxymethyiation, aminolysis and hydrazinolysis has been described. The structure of the products
has been deduced from their elemental analysis and spectral data (UV, IR, IH-NMR and mass spectra). Antimicrobial screening
of some.•products revealed that only the compoun~ 6 showed marked activity towards Streptomyces.

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Published

2000-06-26

How to Cite

Morsy, J. M., Ismail, F., Rahman, R. M. A.-., & Amine, H. A. (2000). ?SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME NEW FULLY SUBSTITUTED 1,2,4-TRIAZINES. Biological Sciences - PJSIR, 43(4), 214–220. Retrieved from http://biostaging.pjsir.org/index.php/biological-sciences/article/view/2035

Issue

Vol. 43 No. 4 (2000): Pakistan Journal of Scientific and Industrial Research

Section

Articles