SYNTHESIS OF SOME 7-AZAINDOLE DERIVATIVES: THEIR CYTOTOXICITY AND ANTIBACTERIAL ACTIVITY

Authors

  • ZAFAR SAEED SAIFY Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan
  • SYED MOAZZAM HAIDER Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan
  • MANSOOR AHMED Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan
  • MOHAMMAD SAEED Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan
  • BINA SHAHEEN SIDDIQUI Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan
  • ABDULLAH KHAN Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan

Keywords:

7-Azaindole, Cytotoxicity, Antibacterial activity.

Abstract

In thecourseofpharmaco-chemical studies, a number of new 7-azaindolederivatives have been prepared.The spectroscopic
techniques such as IH NMR, ElMS, UV and IR were utilized for their structure elucidation. These compounds
were tested against a variety of Gram + ve and Gram-ve bacteria. These compounds were also screened for their cytotoxicity
against Artemia salina. Compound IV displayed significant antibacterial activity amongst all the tested
compounds. Whereas compound VI was found to be the most significant cytotoxic when screened through brine shrimp
bioassay.

Published

2022-06-09

Issue

Vol. 37 No. 10 (1994): Pakistan Journal of Scientific and Industrial Research

Section

Articles

How to Cite

SYNTHESIS OF SOME 7-AZAINDOLE DERIVATIVES: THEIR CYTOTOXICITY AND ANTIBACTERIAL ACTIVITY. (2022). Biological Sciences - PJSIR, 37(10), 439-441. https://biostaging.pjsir.org/index.php/biological-sciences/article/view/2739